Notable Journal Articles

Stephen M. Black serves as a Regents’ Professor with Georgia Regents University.  He aims to share his medical knowledge through peer-reviewed medical journals about heart disease and pulmonary hypertension. Two of his most popular articles  pertain to  increases in pulmonary vascular resistance and acute lung injury in patients with respiratory failure.

Inhaled Nitric Oxide-Induced Rebound Pulmonary Hypertension: Role for Endothelin-1

Stephen M. Black and other highly respectable medical research analysts conducted a research study that linked increases in pulmonary vascular resistance with the acute withdrawal of inhaled Nitric Oxide (NO). In conjunction with pulmonary hypertension, Stephen M. Black and his peers studied Endothelin (ET-1), which is an active peptide produced by the vascular endothelium. The factors derived from Endothelin are pulmonary heart disease and pulmonary hypertension in newborns.

The objective of this study was to determine the effects of inhaled NO on ET-1 production. They did this by comparing six one-month-old lambs who inhaled NO to six lamb models that did not inhale NO. From their research, Stephen M. Black and his team of medical researchers were able to investigate the effects of inhaled NO on ET-1 production through analysis of ET-1 concentrations in the newborn lambs during 24 hours of inhaled NO.

Learn more about this study here: http://ajpheart.physiology.org/content/280/2/H777.full.pdf

New Insights into Acute Lung Injury

In a recent study, Stephen M. Black collected data indicating the causes and effects of acute lung Injury (ALI) and acute respiratory distress syndrome (ARDS). These conditions are both due to progressive respiratory failure relating to acute onset of dyspnea, decreased arterial oxygen pressure, or hypoxemia and bilateral infiltrates on chest radiograms.  A statistics report made by the National Institute of Health states that every year 150,000 people in the United States are diagnosed with severe forms of ALI and ARDS.  In ALI/ARDS patients it is common for the separation between the alveolus and pulmonary circulation to be compromised by endothelial and /or epithelial injury. Undoubtedly, this study shows why lungs are  the organs most susceptible to damage and health issues caused by ALI/ARDS.

Read the full write-up on this study here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862586/